Jack Harley
Reviewed by Dr Michael Yapko
Monday, January 6, 2020
Jack Harley
Monday, January 6, 2020

Stress and IBS - Gut-Brain Link, Causes and Management

Contents

If you’ve ever experienced 'butterflies in your stomach’ then you have felt effects of the stress-gut connection. Stress is associated with a variety of bodily effects and may contribute to irritable bowel syndrome (IBS). Understanding and managing stress can help reduce symptoms of IBS and leave you feeling well again.

What is stress?

Stress is your body’s response to difficult situations that require immediate action or adjustment. Stress may trigger the ‘fight or flight’ response as the body prepares to fight or escape from a perceived threat. This is accompanied by increase in heart rate, release of hormones such as cortisol, reduced blood flow to certain organs and slower digestion.

Types of stress include:

  • Eustress: This is a positive form of stress. It is usually experienced as feelings of excitement and energy.
  • Acute stress: A short-term stress that may be positive or negative.
  • Chronic stress: Long-term stress that may seem never-ending.

Normally, the relaxation response returns the body to normal when the threat is gone. However, in chronic stress the relaxation response does not occur. This is harmful as it may deplete and tax the body and lead to conditions including IBS. (1)

What causes stress?

Causes of stress are known as ‘stressors’. What constitutes a stressor is determined by individual perception – one person’s ‘stress’ may be what another calls a ‘challenge’.

However, certain situations may be more likely to cause stress than others. People may stress from work, personal relationships, financial trouble, or busy schedules. Learning coping strategies for these stressors may reduce stress levels.

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Stress and IBS – Whats the link?

The gut and brain influence one another continually. In prehistoric times, this served us well: stressful situations would activate the ‘fight or flight’ system – blood flow to the stomach would reduce and the bowels empty or tense up. This would allow for more energy to flee or fight.

In today’s world, life-threatening situations are rare but we are still wired the same way. Modern ‘predators’ may come in the form of deadlines, and busy schedules and may cause ongoing stress. This chronic stress is what often leads to gastrointestinal issues such as IBS.

What evidence links stress and IBS?

The link between stress and IBS is well supported by the science, too:

One study showed that chronic stress predicts the severity of IBS symptoms. Levels of  stress and IBS symptoms were documented over 16 months, and almost all changes in IBS symptoms were based on changes in stress. Notably, not one patient with ongoing stress improved in IBS symptoms significantly. (2)

Another study showed people with IBS are more sensitive to pain during stress. When placing their hands in cold water, or listening to unpleasant music, IBS patients were more sensitive to non-painful rectal stimuli than healthy controls. This form of sensitivity to pain in the internal organs is called ‘visceral hypersensitivity’ and is associated with abdominal discomfort in IBS. (3)

How does stress contribute to IBS?

Stress causes many changes in the body, to hormones, nerves, and levels of bacteria in the gut.These changes may lead to IBS and include:  

  • Pain perception: Stress causes higher sensitivity to pain in the colon and rectum, in response to stretching. This leads to abdominal pain in IBS.
  • Brain activation: Brain areas associated with attention are changed in stress, leading to a greater conscious focus on sensations in the body, and more pain.      
  • Gut bacteria: Levels change in response to chronic stress, potentially causing IBS as gut bacteria interact with the nervous system and immune system.
  • Immune system: Becomes activated. Although this may seem like a good thing, it has adverse effects as is the case in an allergic reaction. In particular, the activation of ‘silent’ pain receptor cells increases sensitivity to pain in IBS.
  • Hormonal changes: Include the release of a corticotropin-releasing factor (CRF). This leads to changes in gut bacteria, and the immune system – both of which contribute to IBS. (4)

The gut-brain connection

The changes listed above are features of the ‘gut-brain connection’ – the two-way link between brain and bowels. This link is made up of several parts, including the millions of neurons that surround the gut.

The neurons in the gut are complex and described as the ‘second brain’. This second brain interacts with the actual brain in a number of ways. The brain sends signals to the stomach and intestines to control digestion. Meanwhile the gut may sends feedback signals back to the brain. These are usually unconscious, but in IBS become disrupted and may be felt consciously as pain. (5)

The gut-brain connection is at the heart of IBS. IBS is a ‘functional’ disorder meaning there is no physical damage to the bowels in spite of symptoms. Recognising that there is a psychological component to IBS is crucial for understanding how stress is involved. It also helps explain the strong overlap of psychological disorders and trauma, and IBS.

Trauma and IBS

Psychological illness can be common in people with IBS. These include depression, anxiety and post-traumatic stress disorder (PTSD) and may be worsened by chronic stress. Up to 60% of people with IBS have psychiatric disorders, and these can often be preceded by a major life trauma. (6) These include:

  • Sexual abuse
  • Death of a loved one
  • Emotional abuse
  • Break-up of a serious relationship

This kind of trauma is known as ‘psychosocial stress’ and is strongly linked with the development of IBS. Psychological therapies designed to treat trauma may be especially useful in IBS patients, as up to 50% have experienced trauma. (7)

The biopsychosocial model

The concept of the ‘biopsychosocial model’ is useful for understanding how trauma, stress and other environmental effects may contribute to IBS. As implied by the name, biological, psychological and social factors all play a role in disease, according to the model. Hence, trauma early in life has biological and psychological effects that lead to a heightened sensitivity to pain and in turn, IBS. (8)

The link between psychological and biological effects in disease is helpful for treating IBS. Many of the most effective treatments for IBS reduce stress and anxiety. In this way, psychotherapies may reduce symptoms of IBS.

Stress management for IBS

IBS is a stress-sensitive condition. Several stress management strategies have been shown effective for relieving symptoms of IBS:

Yoga: A 2006 study showed that yoga reduced symptoms of IBS. The program consisted of a one-hour live demonstration, and an instructional video followed daily for four weeks. All measures of IBS symptoms were reduced yoga group, compared to controls on a waiting list. (9)

Cognitive-behavioral therapy (CBT): Several studies show CBT improves symptoms of IBS. Improvements occur as patients adopt more positive beliefs about IBS, and discard damaging beliefs. Improvements can be maintained 6-months after treatment. (10)

Mindfulness training: A 2011 trial showed training in mindfulness reduced bowel-related symptoms and distress. The program emphasized the mind-body connection and present moment awareness. The program lasted eight weeks and substantial results were maintained 3-months after treatment. (11)

Gut-directed hypnotherapy: Hypnotherapy reduced symptoms such as pain, bloating and wind equally to an elimination diet for IBS (low FODMAP). Imagery was used such as suggestions of the gut as a series of watery pipes, after patients were hypnotically induced. Impressively, the improvements were maintained for at least 6-months, and levels of anxiety reduced as an added bonus. (12)

These therapies are effective for IBS. While IBS is not 'all in the mind', the gut-brain connection means targeting the mind through stress management can positively influence perceptions of pain in the gut. Symptoms of stress and anxiety, which worsen IBS, may also improve.

Lifestyle factors for Stress Management

On a day-to-day basis, positive lifestyle adjustments can also reduce chronic stress. This may in turn benefit symptoms of IBS. Important lifestyle factors to consider include:

  • Exercise: Releases chemicals in the brain called endorphins, the body’s ‘natural painkillers’ that reduce stress and improve sleep. Even ten minutes of aerobic exercise can stimulate anti-anxiety effects. (13)
  • Meditation: Has a range of benefits to mind and body, including stress relief. An 8-week program improved overall psychological wellbeing and perceived control over life. Meditation can be easy to learn and even 5 minutes of practice can help reduce stress. (11)
  • Maintaining a healthy diet: Eating whole foods and five serves of vegetables can boost mood and reduce stress. Foods high in fibre, such as wholegrain breads and cereals may lower stress, and citrus fruits and other vitamin C-containing foods reduce anxiety. (14, 15)
  • Maintaining a sense of humour: Helps to connect people and reduces stress levels. Laughter releases endorphins and other healthy hormones and distracts people from anger, stress and other negative emotions. (16)
  • Building supportive relationships: A social support network helps to improve self-esteem and autonomy, reducing stress levels. Feeling supported helps to avoid loneliness, which is associated with depression and anxiety. (17)

A Word from Mindset Health

Irritable bowel syndrome may have severely impact quality of life, and is linked to the stress response. Life events such as trauma are often linked with and activate the 'fight or flight' response. This, in turn, may and effects on the digestive tract and lead to functional gastrointestinal disorders related to the cause of IBS.

To reduce psychological stress, try stress reduction strategies such as deep breathing, or seek professional help in the form of hypnotherapy or cognitive behavioural therapy. The treatment of irritable bowel syndrome is complex, but relaxation techniques may help to restore the digestive system. With this treatment, you will be able to better manage cramping, bloating, abnormal bowel movements and other symptoms of IBS.

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Our Sources

Mindset Health only uses high-quality sources, including peer-reviewed research, to support our articles. We work with experts to ensure our content is helpful, accurate and trustworthy.

1.    Verywell Mind. (2020). How Is Stress Affecting My Health?. [online] Available at: https://www.verywellmind.com/stress-and-health-3145086 [Accessed 3 Jan. 2020]. Link

2.    Bennett, E.J., Tennant, C.C.,Piesse, C., Badcock, C.A. and Kellow, J.E., 1998. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut43(2),pp.256-261. Link

3.    Qin, H.Y., Cheng, C.W., Tang, X.D.and Bian, Z.X., 2014. Impact of psychological stress on irritable bowel syndrome. World journal of gastroenterology: WJG20(39),p.14126. Link

4.    Mayer, E.A., Naliboff, B.D., Chang,L. and Coutinho, S.V., 2001. V. Stress and irritable bowel syndrome. AmericanJournal of Physiology-Gastrointestinal and Liver Physiology280(4),pp.G519-G524. Link

5.    Mayer, E.A. and Tillisch, K., 2011.The brain-gut axis in abdominal pain syndromes. Annual review of medicine62, pp.381-396. Link

6.    Fond, G., Loundou, A., Hamdani, N.,Boukouaci, W., Dargel, A., Oliveira, J., Roger, M., Tamouza, R., Leboyer, M.and Boyer, L., 2014. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Europeanarchives of psychiatry and clinical neuroscience264(8),pp.651-660. Link

7.    Halland M, Almazar A, Lee R,Atkinson E, Larson J, Talley NJ, Saito YA. A case–control study of childhood trauma in the development of irritable bowel syndrome. Neurogastroenterology & Motility. 2014 Jul;26(7):990-8. Link

8.    George, E. and Engel, L., 1980. The clinical application of the biopsychosocial model. American journal ofPsychiatry137(5), pp.535-544. Link

9.    Kavuri, V., Selvan, P., Malamud,A., Raghuram, N. and Selvan, S.R., 2015. Remedial yoga module remarkably improves symptoms in irritable bowel syndrome patients: A 12-week randomized controlled trial. European Journal of Integrative Medicine7(6),pp.595-608. Link

10.Chilcot, J. and Moss-Morris, R.,2013. Changes in illness-related cognitions rather than distress mediate improvements in irritable bowel syndrome (IBS) symptoms and disability following a brief cognitive behavioural therapy intervention. BehaviourResearch and Therapy51(10), pp.690-695. Link

11.Astin, J.A., 1997. Stress reduction through mindfulness meditation. Psychotherapy and psychosomatics66(2),pp.97-106. Link

12.Peters, S.L., Yao, C.K., Philpott,H., Yelland, G.W., Muir, J.G. and Gibson, P.R., 2016. Randomised clinical trial: the efficacy of gut‐directed hypnotherapy is similar to that of the lowFODMAP diet for the treatment of irritable bowel syndrome. Alimentarypharmacology & therapeutics44(5), pp.447-459. Link

13.Berger, B.G. and Owen, D.R., 1988.Stress reduction and mood enhancement in four exercise modes: Swimming, body conditioning, hatha yoga, and fencing. Research quarterly for exercise and sport59(2), pp.148-159. Link

14.Ribeiro, C.U., 2015. Effects oforal vitamin C supplementation on anxiety in students: a double blind, randomized, placebo-controlled trial. Pakistan Journal of Biological Sciences18(1), pp.11-8. Link

15.Taylor, A.M. and Holscher, H.D.,2018. A review of dietary and microbial connections to depression, anxiety, and stress. Nutritional neuroscience, pp.1-14. Link

16.Moran, C.C. and Hughes, L.P., 2006.Coping with stress: Social work students and humour. Social WorkEducation25(5), pp.501-517. Link

17.Cobb, S., 1976. Social support as a moderator of life stress. Psychosomatic medicine. Link

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